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Creative BioMart Released SARS-CoV-2 Related Proteins and Druggable Target Proteins Products

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Creative BioMart Released SARS-CoV-2 Related Proteins and Druggable Target Proteins Products

May 28
16:22 2020
Creative BioMart has collected many SARS-CoV-2 related proteins and druggable target proteins to help discover antiviral therapies against SARS-CoV-2 and other deadly coronavirus strains.

New York, USA – The COVID-19 outbreak has caused large numbers of death, as well as social and economic chaos worldwide. SARS-CoV-2 virus is the causative agent of this respiratory disease. Creative BioMart has collected many SARS-CoV-2 related proteins and druggable target proteins to help discover antiviral therapies against SARS-CoV-2 and other deadly coronavirus strains.

It has been found that SARS-CoV-2 binds to host cell receptors through its surface spike (S) protein and is endocytosed into cells through clathrin-mediated membrane fusion. The relationship and affinity of the host cell receptor with the virus surface protein determines the infectivity and cytophilic nature of the virus. The pathogenicity and invasiveness of the virus are related to the type and function of the host cell. Crystal structure analysis confirmed that angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV-2 S protein, and the affinity of the two is 10-20 times that of SARS-CoV and ACE2, which is super infectious for SARS-CoV-2.

So far, no clinically available antiviral drugs have been developed that can be used for SARS-CoV, SARS-CoV-2 or MERS-CoV. Several studies identified hundreds of protein interactions between SARS-CoV-2 proteins and human proteins using affinity purification-mass spectrometry, including DNA replication (Nsp1), epigenetic and gene expression modulators (Nsp5, Nsp8, Nsp13, E), vesicular trafficking (Nsp6, Nsp7, Nsp10, Nsp13, Nsp15, Orf3a, E, Orf8), lipid modification (Spike), RNA processing and regulation (Nsp8, N), ubiquitin ligase (Orf10), signaling (Nsp8, Nsp13, N, Orf9b), nuclear transport tools (Nsp9, Nsp15, Orf6), cytoskeleton (Nsp1, Nsp13), mitochondria (Nsp4, Nsp8, Orf9c) and extracellular matrix (Nsp9). The results of the data analysis indicate that viral proteins are implicated in a wide variety of biological processes, including protein trafficking, translation, transcription and ubiquitination regulation.

Featured interaction proteins at Creative BioMart include:

Recombinant Human ACE2, His-tagged
Recombinant Human ACE2, Fc-tagged
Recombinant Human ACE2, mouse IgG1 Fc-tagged
Recombinant Human TMPRSS2 Protein (106-492 aa), His-tagged
Recombinant Human TMPRSS2, his-tagged
Recombinant Human ACE2 protein, His/Avi-tagged

Druggable targets include:

BRD2, BRD4, CSNK2A2, HDAC2, ATP6AP1, SIGMAR1, TMEM97, COMT, PTGES2, NDUFS1, RIPK1, GLA, LOX, MARK2, F2RL1, ABCC1, etc.

To get a whole view of the SARS-CoV-2 Related Proteins and Druggable Target Proteins Products provided by Creative BioMart, please visit https://www.creativebiomart.net/SARS-CoV-2-Proteins-and-Their-Target-Proteins.htm.

Media Contact
Company Name: Creative BioMart
Contact Person: Caroline Green
Email: Send Email
Phone: 1-631-619-7922
Country: United States
Website: https://www.creativebiomart.net

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